Ruth Nussinov Selected Research

Calmodulin (Calcium-Dependent Activator Protein)

12/2021	The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations.
1/2021	The structural basis of Akt PH domain interaction with calmodulin.
1/2019	Is Nanoclustering essential for all oncogenic KRas pathways? Can it explain why wild-type KRas can inhibit its oncogenic variant?
6/2018	Calmodulin and IQGAP1 activation of PI3Kα and Akt in KRAS, HRAS and NRAS-driven cancers.
11/2017	Phosphorylated Calmodulin Promotes PI3K Activation by Binding to the SH2 Domains.
1/2017	Calmodulin and PI3K Signaling in KRAS Cancers.
1/2017	Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
7/2016	K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?
1/2016	A New View of Ras Isoforms in Cancers.
9/2015	The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.

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Ruth Nussinov Research Topics

Disease

73	Neoplasms (Cancer) 06/2022 - 01/2008
35	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 02/2006
12	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 04/2006
6	Carcinogenesis 01/2022 - 08/2013
6	Amyloid Plaque 10/2014 - 10/2009
5	Breast Neoplasms (Breast Cancer) 02/2021 - 12/2006
5	Parkinson Disease (Parkinson's Disease) 01/2021 - 10/2016
5	Adenocarcinoma 01/2020 - 09/2015
5	Inflammation (Inflammations) 11/2019 - 08/2013
4	Drug-Related Side Effects and Adverse Reactions 12/2019 - 06/2012
4	Amyloidosis 06/2018 - 06/2003
4	Lung Neoplasms (Lung Cancer) 10/2016 - 09/2015
3	Neoplasm Metastasis (Metastasis) 11/2019 - 01/2014
3	Type 2 Diabetes Mellitus (MODY) 09/2018 - 01/2016
3	Memory Disorders (Memory Loss) 10/2014 - 02/2012
3	Down Syndrome (Down's Syndrome) 05/2011 - 08/2009
2	COVID-19 04/2022 - 12/2020
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 03/2016
2	Leukemia 01/2018 - 01/2012
2	Proteostasis Deficiencies 10/2014 - 02/2012
2	Infections 06/2013 - 04/2007
1	Neurodevelopmental Disorders 06/2022
1	Adenocarcinoma of Lung 01/2022
1	Colorectal Neoplasms (Colorectal Cancer) 11/2021
1	Multiple Sclerosis 01/2020
1	Substance-Related Disorders (Drug Abuse) 01/2020
1	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 10/2019
1	Triple Negative Breast Neoplasms 01/2019
1	Melanoma (Melanoma, Malignant) 01/2019
1	Genomic Instability 01/2019
1	Persistent Infection 01/2019

Drug/Important Bio-Agent (IBA)

38	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2003
24	Peptides (Polypeptides)IBA 01/2021 - 04/2007
20	Pharmaceutical PreparationsIBA 04/2022 - 06/2013
19	Amyloid (Amyloid Fibrils)IBA 01/2021 - 10/2006
10	Calmodulin (Calcium-Dependent Activator Protein)IBA 12/2021 - 09/2015
9	Protein Isoforms (Isoforms)IBA 01/2020 - 09/2015
6	cysteinyl-arginyl-glutamyl-lysyl-alanylIBA 01/2013 - 07/2008
5	CytokinesIBA 01/2022 - 01/2014
5	Amino Acids FDA Link 01/2021 - 06/2009
5	Ion Channels (Ion Channel)IBA 01/2017 - 10/2009
4	LipidsIBA 05/2021 - 08/2015
4	CalciumIBA 01/2017 - 12/2009
4	Blood Proteins (Serum Proteins)IBA 01/2013 - 01/2009
3	Monomeric GTP-Binding ProteinsIBA 06/2022 - 01/2016
3	Phosphotransferases (Kinase)IBA 01/2022 - 08/2013
3	ras ProteinsIBA 01/2022 - 09/2015
3	SynucleinsIBA 01/2021 - 10/2016
3	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2019
2	Interleukin-1 (Interleukin 1)IBA 06/2022 - 02/2014
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022 - 04/2014
2	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2021 - 07/2016
2	Superoxide Dismutase-1IBA 01/2021 - 03/2016
2	Aripiprazole (Abilify)FDA Link 01/2020 - 12/2019
2	Risperidone (Risperdal Consta)FDA LinkGeneric 01/2020 - 12/2019
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2019 - 01/2008
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2018 - 04/2012
2	Protein Kinases (Protein Kinase)IBA 10/2018 - 08/2013
2	Islet Amyloid PolypeptideIBA 09/2018 - 01/2016
2	SolutionsIBA 10/2017 - 03/2011
2	polyglutamineIBA 11/2016 - 04/2006
2	tau Proteins (tau Protein)IBA 11/2016 - 01/2016
2	ZincIBA 03/2016 - 05/2010
2	Toll-Like Receptors (Toll-Like Receptor)IBA 08/2015 - 08/2013
2	FibrinIBA 01/2013 - 10/2010
2	Peptide Hydrolases (Proteases)FDA Link 06/2011 - 06/2009
2	Amyloid beta-PeptidesIBA 04/2010 - 02/2006
1	Type II Tumor Necrosis Factor ReceptorsIBA 01/2022
1	Mutant Proteins (Protein, Mutant)IBA 12/2021
1	Immune Checkpoint InhibitorsIBA 11/2021
1	Phosphatidylinositols (Phosphatidylinositol)IBA 05/2021
1	ErbB Receptors (EGF Receptor)IBA 02/2021
1	IgA receptor (protein B)IBA 02/2021
1	human ERBB2 proteinIBA 02/2021
1	Trastuzumab (Herceptin)FDA Link 02/2021
1	Monoclonal AntibodiesIBA 02/2021
1	Epidermal Growth Factor (EGF)IBA 02/2021
1	LigandsIBA 01/2021
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2021
1	Messenger RNA (mRNA)IBA 01/2021
1	SurvivinIBA 01/2021
1	GTP Phosphohydrolases (GTPases)IBA 01/2021
1	sepantroniumIBA 01/2021
1	MicroRNAs (MicroRNA)IBA 01/2021
1	cdc42 GTP-Binding ProteinIBA 01/2021
1	crenezumabIBA 10/2020
1	gantenerumabIBA 10/2020
1	AlpelisibIBA 06/2020
1	Topotecan (Hycamtin)FDA LinkGeneric 01/2020
1	Therapeutic UsesIBA 01/2020
1	ChromatinIBA 01/2020
1	Haloperidol (Haldol)FDA LinkGeneric 01/2020
1	AutoantigensIBA 10/2019
1	Small Cytoplasmic RNAIBA 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 01/2019
1	wogonosideIBA 01/2019
1	Angiogenesis InhibitorsIBA 01/2019

Therapy/Procedure

17	Therapeutics 01/2022 - 03/2011
7	Precision Medicine 01/2022 - 10/2010
3	Immunotherapy 11/2021 - 03/2014